Dr. Lisenka Vissers is head of the Translational Genomics team, which focuses on the evaluation and optimization of novel genomic technologies for diagnostic implementation. The team exists of 2 assistant professors, 4 laboratory technicians and 3 bioinformaticians.
Her research has focused on the optimization and large-scale implementation of high-throughput, state-of-the art genomic technologies for the study of human genetic disease. During her PhD project, she has demonstrated record of productive and successful research leading to improved patient care by the implementation of array CGH for patients with intellectual disability (ID) into routine diagnostics as well as by the identification of novel syndromes and disease-causing genes.
In 2008, Lisenka obtained a veni grant and used this to apply next generation sequencing to identify novel disease genes. She was the first to use family-based whole exome sequencing for the identification of de novo mutations creating a paradigm shift in the field of medical genetics. Also, the achieved results provided a founding base to assess the diagnostic yield of exome sequencing in a routine diagnostic setting. The next frontiers in routine clinical diagnosis will, amongst others, include the implementation of whole genome sequencing as well as improving the clinical interpretation of (non-coding) genetic variation.